InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Glul

Summary

InnateDB Gene

IDBG-199433.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Glul

Gene Name

glutamate-ammonia ligase (glutamine synthetase)

Synonyms

Glns; GS

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026473

Encoded Proteins

IDBP-199437

glutamate-ammonia ligase (glutamine synthetase)

IDBP-535206

glutamate-ammonia ligase (glutamine synthetase)

IDBP-536512

glutamate-ammonia ligase (glutamine synthetase)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135821:
The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia. Glutamine is a main source of energy and is involved in cell proliferation, inhibition of apoptosis, and cell signaling. This gene is expressed during early fetal stages, and plays an important role in controlling body pH by removing ammonia from circulation. Mutations in this gene are associated with congenital glutamine deficiency. Several alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:153899944-153909723

Strand

Forward strand

Band

Transcripts

ENSMUST00000086199	ENSMUSP00000083375
ENSMUST00000139476	ENSMUSP00000114377
ENSMUST00000140685	ENSMUSP00000123157
ENSMUST00000153134
ENSMUST00000154576

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004351	glutamate decarboxylase activity
GO:0004356	glutamate-ammonia ligase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016595	glutamate binding
GO:0030145	manganese ion binding
GO:0042802	identical protein binding
GO:0045503	dynein light chain binding

Biological Process

GO:0006536	glutamate metabolic process
GO:0006542	glutamine biosynthetic process
GO:0006807	nitrogen compound metabolic process
GO:0008283	cell proliferation
GO:0009267	cellular response to starvation
GO:0009749	response to glucose
GO:0032024	positive regulation of insulin secretion
GO:0050679	positive regulation of epithelial cell proliferation
GO:0051260	protein homooligomerization
GO:0051968	positive regulation of synaptic transmission, glutamatergic

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005791	rough endoplasmic reticulum
GO:0042995	cell projection
GO:0043005	neuron projection
GO:0043204	perikaryon
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex
GO:0043679	axon terminus
GO:0044297	cell body
GO:0070062	extracellular vesicular exosome
GO:0097386	glial cell projection