Mus musculus Protein: Ltk | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||
InnateDB Protein | IDBP-199624.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | Ltk | ||||||||||||||||||
Protein Name | leukocyte tyrosine kinase | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||
Ensembl Protein | ENSMUSP00000028759 | ||||||||||||||||||
InnateDB Gene | IDBG-199622 (Ltk) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Orphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport (By similarity). {ECO:0000250}. | ||||||||||||||||||
Subcellular Localization | Cell membrane {ECO:0000269PubMed:8995435}; Single-pass type I membrane protein {ECO:0000269PubMed:8995435}.Isoform A: Endoplasmic reticulum. Note=Retained in the endoplasmic reticulum.Isoform B: Endoplasmic reticulum. Note=Retained in the endoplasmic reticulum. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Subsets of lymphoid and neuronal cells. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
|
||||||||||||||||||
Gene Ontology | |||||||||||||||||||
Molecular Function |
|
||||||||||||||||||
Biological Process |
|
||||||||||||||||||
Cellular Component |
|
||||||||||||||||||
Protein Structure and Domains | |||||||||||||||||||
PDB ID | MGI:96840 | ||||||||||||||||||
InterPro |
IPR000719
Protein kinase domain IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain IPR011009 Protein kinase-like domain IPR020635 Tyrosine-protein kinase, catalytic domain |
||||||||||||||||||
PFAM |
PF00069
PF07714 |
||||||||||||||||||
PRINTS |
PR00109
|
||||||||||||||||||
PIRSF | |||||||||||||||||||
SMART |
SM00220
SM00219 |
||||||||||||||||||
TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | P08923 | ||||||||||||||||||
PhosphoSite | PhosphoSite-P08923 | ||||||||||||||||||
TrEMBL | F6V2R5 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 17005 | ||||||||||||||||||
UniGene | Mm.1740 | ||||||||||||||||||
RefSeq | NP_976220 | ||||||||||||||||||
MGI ID | |||||||||||||||||||
MGI Symbol | Ltk | ||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS16608 | ||||||||||||||||||
HPRD | |||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AL844536 M90470 X07984 X52621 | ||||||||||||||||||
GenPept | AAA39451 CAA30793 CAA36848 CAM18081 | ||||||||||||||||||