Mus musculus Gene: Ltk
Summary
InnateDB Gene IDBG-199622.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ltk
Gene Name leukocyte tyrosine kinase
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000027297
Encoded Proteins
leukocyte tyrosine kinase
leukocyte tyrosine kinase
leukocyte tyrosine kinase
leukocyte tyrosine kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Four alternatively spliced transcript variants encoding different isoforms have been described for this gene. These transcripts are expressed in a tissue-specific manner in lymphocytes, brain and neuroblastoma cells, and the encoded isoforms exhibit different subcellular localization. The lymphocyte and brain specific variants initiate translation at non-AUG (CUG) start codons. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:119751320-119760431
Strand Reverse strand
Band E5
Transcripts
ENSMUST00000028759 ENSMUSP00000028759
ENSMUST00000082130 ENSMUSP00000080774
ENSMUST00000140224 ENSMUSP00000123020
ENSMUST00000127470
ENSMUST00000134295
ENSMUST00000182203 ENSMUSP00000138201
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008283 cell proliferation
GO:0010666 positive regulation of cardiac muscle cell apoptotic process
GO:0010976 positive regulation of neuron projection development
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0043066 negative regulation of apoptotic process
GO:0071300 cellular response to retinoic acid
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
Pathways
NETPATH
REACTOME
KEGG
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.1740
RefSeq NM_008523 NM_203345 NM_206941 NM_206942
OMIM
CCDS CCDS16608 CCDS16609 CCDS50674
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas