InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Serpinf1

Summary

InnateDB Protein

IDBP-199869.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Serpinf1

Protein Name

serine (or cysteine) peptidase inhibitor, clade F, member 1

Synonyms

AI195227; EPC-1; Pedf; Pedfl; Sdf3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000000769

InnateDB Gene

IDBG-199867 (Serpinf1)

Protein Structure

UniProt Annotation

Function

Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. {ECO:0000269PubMed:12632345}.

Subcellular Localization

Secreted. Melanosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in the liver, gastric glandular mucosa and renal tubules. It is also expressed in the brain, heart, lung retina and testes. {ECO:0000269PubMed:9565647, ECO:0000269PubMed:9614124}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity

Biological Process

GO:0001822	kidney development
GO:0007568	aging
GO:0007614	short-term memory
GO:0010447	response to acidity
GO:0010596	negative regulation of endothelial cell migration
GO:0010629	negative regulation of gene expression
GO:0010951	negative regulation of endopeptidase activity
GO:0010976	positive regulation of neuron projection development
GO:0016525	negative regulation of angiogenesis
GO:0030162	regulation of proteolysis
GO:0032526	response to retinoic acid
GO:0042698	ovulation cycle
GO:0046685	response to arsenic-containing substance
GO:0050728	negative regulation of inflammatory response
GO:0050769	positive regulation of neurogenesis
GO:0051384	response to glucocorticoid
GO:0060041	retina development in camera-type eye
GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0071279	cellular response to cobalt ion
GO:0071300	cellular response to retinoic acid
GO:0071333	cellular response to glucose stimulus
GO:0071549	cellular response to dexamethasone stimulus
GO:1901215	negative regulation of neuron death

Cellular Component

GO:0005576	extracellular region
GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0030424	axon
GO:0031012	extracellular matrix
GO:0042470	melanosome
GO:0043025	neuronal cell body
GO:0043203	axon hillock
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome