InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sos1

Summary

InnateDB Protein

IDBP-199951.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sos1

Protein Name

son of sevenless homolog 1 (Drosophila)

Synonyms

4430401P03Rik; 9630010N06; AI449023;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000067786

InnateDB Gene

IDBG-199949 (Sos1)

Protein Structure

UniProt Annotation

Function

Promotes the exchange of Ras-bound GDP by GTP. Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity. {ECO:0000269PubMed:10499589, ECO:0000269PubMed:11524436}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in most embryonic and adult tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	36 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	52 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005088	Ras guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0007265	Ras protein signal transduction
GO:0032318	regulation of Ras GTPase activity
GO:0032319	regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0051057	positive regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0014069	postsynaptic density
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

MGI:98354

InterPro

IPR000219 Dbl homology (DH) domain
IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001849 Pleckstrin homology domain
IPR001895 Guanine-nucleotide dissociation stimulator CDC25
IPR007125 Histone core
IPR009072 Histone-fold
IPR023578 Ras guanine nucleotide exchange factor, domain

PFAM

PF00621
PF00618
PF00169
PF00617
PF00125

PRINTS

PIRSF

SMART

SM00325
SM00229
SM00233
SM00147

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q62245