InnateDB Protein
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IDBP-200582.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Dgat2
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Protein Name
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diacylglycerol O-acyltransferase 2
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Synonyms
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0610010B06Rik; ARAT; DGAT-2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000033001
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InnateDB Gene
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IDBG-200580 (Dgat2)
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Protein Structure
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Function |
Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides. Functions also as an acyl-CoA retinol acyltransferase (ARAT) (By similarity). {ECO:0000250}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Lipid droplet {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Predominantly expressed in liver. Also expressed in testis. {ECO:0000269PubMed:11481335}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0003846
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2-acylglycerol O-acyltransferase activity
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GO:0004144
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diacylglycerol O-acyltransferase activity
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GO:0016747
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transferase activity, transferring acyl groups other than amino-acyl groups
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GO:0042803
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protein homodimerization activity
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GO:0050252
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retinol O-fatty-acyltransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1915050
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InterPro |
IPR007130
Diacylglycerol acyltransferase
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PFAM |
PF03982
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9DCV3
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PhosphoSite |
PhosphoSite-Q9DCV3
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
67800
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UniGene |
Mm.485614
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RefSeq |
NP_080660
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MGI ID |
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MGI Symbol |
Dgat2
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OMIM |
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CCDS |
CCDS21477
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HPRD |
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IMGT |
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EMBL |
AF384160
AK002443
BC043447
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GenPept |
AAH43447
AAK84175
BAB22105
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