InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ywhae

Summary

InnateDB Protein

IDBP-200599.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ywhae

Protein Name

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide

Synonyms

AU019196;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000070993

InnateDB Gene

IDBG-200597 (Ywhae)

Protein Structure

UniProt Annotation

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Subcellular Localization

Cytoplasm {ECO:0000250}. Melanosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 187 experimentally validated interaction(s) in this database.
They are also associated with 266 interaction(s) predicted by orthology.

Experimentally validated
Total	187 [view]
Protein-Protein	187 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	266 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015459	potassium channel regulator activity
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding
GO:0023026	MHC class II protein complex binding
GO:0032403	protein complex binding
GO:0042826	histone deacetylase binding
GO:0044325	ion channel binding
GO:0044822	poly(A) RNA binding
GO:0046982	protein heterodimerization activity
GO:0050815	phosphoserine binding
GO:0051219	phosphoprotein binding

Biological Process

GO:0001764	neuron migration
GO:0006605	protein targeting
GO:0021762	substantia nigra development
GO:0021766	hippocampus development
GO:0021987	cerebral cortex development
GO:0035308	negative regulation of protein dephosphorylation
GO:0060306	regulation of membrane repolarization
GO:1901016	regulation of potassium ion transmembrane transporter activity
GO:1902309	negative regulation of peptidyl-serine dephosphorylation

Cellular Component

GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005871	kinesin complex
GO:0016020	membrane
GO:0030424	axon
GO:0030659	cytoplasmic vesicle membrane
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome