Mus musculus Gene: Ywhae | |||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||
InnateDB Gene | IDBG-200597.6 | ||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
Gene Symbol | Ywhae | ||||||||||||||||||||||||||
Gene Name | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | ||||||||||||||||||||||||||
Synonyms | AU019196 | ||||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000020849 | ||||||||||||||||||||||||||
Encoded Proteins |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
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Protein Structure | |||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||
Summary |
[Homo sapiens] YWHAE (14-3-3 epsilon) interacts with key components of mitogen-activated protein kinase (MAPK)signal module for selective modulation of the TNF-alpha-induced time course-dependent NF-kappaB activity.
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Entrez Gene | |||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108953:
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008] This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100%% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008] |
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Gene Information | |||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||
Genomic Location | Chromosome 11:75732869-75765845 | ||||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||||
Band | B5 | ||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 187 experimentally validated interaction(s) in this database.
They are also associated with 266 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||
REACTOME |
Recruitment of mitotic centrosome proteins and complexes pathway
Apoptosis pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Loss of Nlp from mitotic centrosomes pathway
Membrane Trafficking pathway
Cellular responses to stress pathway
Cell Cycle pathway
Activation of BAD and translocation to mitochondria pathway
Mitotic G2-G2/M phases pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
NADE modulates death signalling pathway
Cellular response to heat stress pathway
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
Signaling by Hippo pathway
Regulation of PLK1 Activity at G2/M Transition pathway
Signalling by NGF pathway
HSF1 activation pathway
Activation of BH3-only proteins pathway
Signal Transduction pathway
Regulation of HSF1-mediated heat shock response pathway
p75 NTR receptor-mediated signalling pathway
Translocation of GLUT4 to the plasma membrane pathway
Centrosome maturation pathway
Intrinsic Pathway for Apoptosis pathway
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KEGG |
Cell cycle pathway
Neurotrophin signaling pathway pathway
Oocyte meiosis pathway
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INOH |
Wnt signaling pathway pathway
Insulin receptor signaling pathway
Fas signaling pathway pathway
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PID NCI | |||||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||
NETPATH |
Alpha6Beta4Integrin pathway
TNFalpha pathway
Hedgehog pathway
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REACTOME |
Regulation of PLK1 Activity at G2/M Transition pathway
Loss of Nlp from mitotic centrosomes pathway
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
Recruitment of mitotic centrosome proteins and complexes pathway
NADE modulates death signalling pathway
Signaling by Hippo pathway
Activation of BAD and translocation to mitochondria pathway
Translocation of GLUT4 to the plasma membrane pathway
Cellular responses to stress pathway
Signalling by NGF pathway
Regulation of HSF1-mediated heat shock response pathway
p75 NTR receptor-mediated signalling pathway
Apoptosis pathway
Signal Transduction pathway
Cell Cycle pathway
Activation of BH3-only proteins pathway
Centrosome maturation pathway
G2/M Transition pathway
Cellular response to heat stress pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
Cell Cycle, Mitotic pathway
Intrinsic Pathway for Apoptosis pathway
Mitotic G2-G2/M phases pathway
HSF1 activation pathway
Membrane Trafficking pathway
G2/M Transition pathway
Regulation of HSF1-mediated heat shock response pathway
Activation of BH3-only proteins pathway
Cellular responses to stress pathway
Translocation of GLUT4 to the plasma membrane pathway
Cell Cycle, Mitotic pathway
Loss of Nlp from mitotic centrosomes pathway
Mitotic G2-G2/M phases pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
Cell Cycle pathway
Signal Transduction pathway
HSF1 activation pathway
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
Intrinsic Pathway for Apoptosis pathway
Signalling by NGF pathway
Cellular response to heat stress pathway
NADE modulates death signalling pathway
Activation of BAD and translocation to mitochondria pathway
Regulation of PLK1 Activity at G2/M Transition pathway
p75 NTR receptor-mediated signalling pathway
Recruitment of mitotic centrosome proteins and complexes pathway
Centrosome maturation pathway
Signaling by Hippo pathway
Apoptosis pathway
Membrane Trafficking pathway
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KEGG |
Cell cycle pathway
Neurotrophin signaling pathway pathway
Oocyte meiosis pathway
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INOH |
Wnt signaling pathway pathway
Insulin receptor signaling pathway
Fas signaling pathway pathway
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PID NCI |
IGF1 pathway
p75(NTR)-mediated signaling
Signaling events mediated by HDAC Class II
TGF-beta receptor signaling
Lissencephaly gene (LIS1) in neuronal migration and development
Regulation of Telomerase
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Cross-References | |||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||
UniGene | Mm.234700 Mm.471625 | ||||||||||||||||||||||||||
RefSeq | NM_009536 | ||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||
CCDS | CCDS25056 | ||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||