Version 5.4
Mus musculus Protein: Vps39
Summary
InnateDB Protein IDBP-200652.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Vps39
Protein Name vacuolar protein sorting 39 (yeast)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000099559
InnateDB Gene IDBG-200650 (Vps39)
Protein Structure
UniProt Annotation
Function May play a role in clustering and fusion of late endosomes and lysosomes (By similarity). Regulator of TGF- beta/activin signaling, inhibiting SMAD3- and activating SMAD2- dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3- dependent transcription and relieve SMAD3 inhibition of SMAD2- dependent promoters, thus increasing SMAD2-dependent transcription (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Lysosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Late endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005083 small GTPase regulator activity
GO:0005515 protein binding
Biological Process
GO:0006886 intracellular protein transport
GO:0016192 vesicle-mediated transport
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0005765 lysosomal membrane
GO:0030897 HOPS complex
GO:0031902 late endosome membrane
Protein Structure and Domains
PDB ID MGI:2443189
InterPro IPR000547 Clathrin, heavy chain/VPS, 7-fold repeat
IPR001180 Citron-like
IPR017986 WD40-repeat-containing domain
IPR019452 Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 1
IPR019453 Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain 2
PFAM PF00637
PF00780
PF10366
PF10367
PRINTS
PIRSF
SMART SM00299
SM00036
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R5L3
PhosphoSite PhosphoSite-Q8R5L3
TrEMBL Q3USV9
UniProt Splice Variant
Entrez Gene 269338
UniGene Mm.246131
RefSeq NP_671495
MGI ID
MGI Symbol Vps39
OMIM
CCDS CCDS38210
HPRD
IMGT
EMBL AF281050 AF281051 AK140041 AK170831 BC007479
GenPept AAH07479 AAL79766 AAL79767 BAE24221 BAE42059

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca