Version 5.4
Mus musculus Protein: Neu3
Summary
InnateDB Protein IDBP-200897.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Neu3
Protein Name neuraminidase 3
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000045222
InnateDB Gene IDBG-200895 (Neu3)
Protein Structure
UniProt Annotation
Function Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates. {ECO:0000269PubMed:10713120}.
Subcellular Localization Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in heart, brain and cerebral cortex. {ECO:0000269PubMed:10713120}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016997 alpha-sialidase activity
GO:0052794 exo-alpha-(2->3)-sialidase activity
GO:0052795 exo-alpha-(2->6)-sialidase activity
GO:0052796 exo-alpha-(2->8)-sialidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006689 ganglioside catabolic process
GO:0009313 oligosaccharide catabolic process
Cellular Component
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:1355305
InterPro IPR011040 Sialidases
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JMH7
PhosphoSite PhosphoSite-Q9JMH7
TrEMBL Q543I9
UniProt Splice Variant
Entrez Gene 50877
UniGene Mm.444421
RefSeq NP_057929
MGI ID
MGI Symbol Neu3
OMIM
CCDS CCDS21489
HPRD
IMGT
EMBL AB026842 AK050428 AK134405 BC116892 BC116924 CH466531
GenPept AAI16893 AAI16925 BAA92868 BAC34251 BAE22130 EDL16409

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca