InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atp6v0a2

Summary

InnateDB Protein

IDBP-200996.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp6v0a2

Protein Name

ATPase, H+ transporting, lysosomal V0 subunit A2

Synonyms

8430408C20Rik; AI385560; ATP6a2; Atp6n1d; Atp6n2; AW489264; C76904; ISF; J6B7; SHIF; Stv1; Tj6; TJ6M; TJ6s; V-ATPase 116 kDa; V-ATPase a2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000039737

InnateDB Gene

IDBG-200994 (Atp6v0a2)

Protein Structure

UniProt Annotation

Function

Part of the proton channel of V-ATPases (By similarity). Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH. {ECO:0000250, ECO:0000269PubMed:16415858}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:16415858}; Multi-pass membrane protein {ECO:0000269PubMed:16415858}. Endosome membrane {ECO:0000269PubMed:16415858}. Note=In kidney proximal tubules, detected in subapical early endosomes.

Disease Associations

Tissue Specificity

Relatively high expression in kidney and liver. Lower levels in the spleen, testis, and skeletal muscle. Also expressed in the thymus. {ECO:0000269PubMed:11375395}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015078	hydrogen ion transmembrane transporter activity

Biological Process

GO:0015991

ATP hydrolysis coupled proton transport

Cellular Component

GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain
GO:0001669	acrosomal vesicle
GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0016021	integral component of membrane
GO:0033179	proton-transporting V-type ATPase, V0 domain