Mus musculus Protein: Ssh2 | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Protein | IDBP-201410.6 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | Ssh2 | ||||||||||||||
Protein Name | slingshot homolog 2 (Drosophila) | ||||||||||||||
Synonyms | |||||||||||||||
Species | Mus musculus | ||||||||||||||
Ensembl Protein | ENSMUSP00000042625 | ||||||||||||||
InnateDB Gene | IDBG-201408 (Ssh2) | ||||||||||||||
Protein Structure | |||||||||||||||
UniProt Annotation | |||||||||||||||
Function | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269PubMed:14531860}. | ||||||||||||||
Subcellular Localization | Cytoplasm, cytoskeleton {ECO:0000269PubMed:14531860}. Cell junction, focal adhesion {ECO:0000269PubMed:14531860}. Note=Colocalizes with filamentous actin in the cytoplasm and the cell periphery. Also localizes to focal adhesions. | ||||||||||||||
Disease Associations | |||||||||||||||
Tissue Specificity | Expressed in brain, heart, liver, skeletal muscle, testis and thymus. Also expressed at lower levels in kidney, small intestine and spleen. {ECO:0000269PubMed:14531860}. | ||||||||||||||
Comments | |||||||||||||||
Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||
PDB ID | MGI:2679255 | ||||||||||||||
InterPro |
IPR000340
Dual specificity phosphatase, catalytic domain IPR000387 Protein-tyrosine/Dual specificity phosphatase IPR014876 DEK, C-terminal IPR020422 Dual specificity phosphatase, subgroup, catalytic domain IPR029021 Protein-tyrosine phosphatase-like |
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PFAM |
PF00782
PF08766 |
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PRINTS | |||||||||||||||
PIRSF | |||||||||||||||
SMART |
SM00195
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TIGRFAMs | |||||||||||||||
Post-translational Modifications | |||||||||||||||
Modification | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | Q5SW75 | ||||||||||||||
PhosphoSite | PhosphoSite-Q5SW75 | ||||||||||||||
TrEMBL | |||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 237860 | ||||||||||||||
UniGene | Mm.475485 | ||||||||||||||
RefSeq | NP_808378 | ||||||||||||||
MGI ID | |||||||||||||||
MGI Symbol | Ssh2 | ||||||||||||||
OMIM | |||||||||||||||
CCDS | CCDS25076 | ||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | AB099288 AK155232 AK158449 AK170142 AK173243 AL606724 AL607072 AL663066 BC141392 BC141393 | ||||||||||||||
GenPept | AAI41393 AAI41394 BAC97811 BAD32521 BAE33137 BAE34514 BAE41593 CAI24906 CAI24907 CAI35939 CAI35940 CAI51882 CAI52040 | ||||||||||||||