InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Scap

Summary

InnateDB Protein

IDBP-202001.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Scap

Protein Name

SREBF chaperone

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000095953

InnateDB Gene

IDBG-201997 (Scap)

Protein Structure

UniProt Annotation

Function

Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway. {ECO:0000250UniProtKB:P97260, ECO:0000269PubMed:11358865, ECO:0000269PubMed:9854040}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250UniProtKB:P97260}; Multi-pass membrane protein {ECO:0000250UniProtKB:P97260}. Golgi apparatus membrane {ECO:0000250UniProtKB:P97260}; Multi-pass membrane protein {ECO:0000250UniProtKB:P97260}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250UniProtKB:P97260}; Multi-pass membrane protein {ECO:0000250UniProtKB:P97260}. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols. {ECO:0000250UniProtKB:P97260}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008158	hedgehog receptor activity
GO:0015485	cholesterol binding
GO:0032403	protein complex binding

Biological Process

GO:0001666	response to hypoxia
GO:0007568	aging
GO:0008203	cholesterol metabolic process
GO:0019217	regulation of fatty acid metabolic process
GO:0032868	response to insulin
GO:0032933	SREBP signaling pathway
GO:0042304	regulation of fatty acid biosynthetic process
GO:0045540	regulation of cholesterol biosynthetic process

Cellular Component

GO:0000139	Golgi membrane
GO:0005789	endoplasmic reticulum membrane
GO:0012507	ER to Golgi transport vesicle membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex