Version 5.4
Mus musculus Protein: Phf12
Summary
InnateDB Protein IDBP-202015.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Phf12
Protein Name PHD finger protein 12
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000044990
InnateDB Gene IDBG-202013 (Phf12)
Protein Structure
UniProt Annotation
Function Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May also repress transcription in a SIN3A-independent manner through recruitment of functional AES complexes to DNA (By similarity). {ECO:0000250UniProtKB:Q96QT6}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed mainly in heart, brain, lung, liver and testis. {ECO:0000269PubMed:11390640}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001106 RNA polymerase II transcription corepressor activity
GO:0001222 transcription corepressor binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0016580 Sin3 complex
GO:0017053 transcriptional repressor complex
Protein Structure and Domains
PDB ID MGI:1924057
InterPro IPR000253 Forkhead-associated (FHA) domain
IPR001965 Zinc finger, PHD-type
IPR008984 SMAD/FHA domain
IPR011011 Zinc finger, FYVE/PHD-type
IPR019787 Zinc finger, PHD-finger
PFAM PF00498
PF00628
PRINTS
PIRSF
SMART SM00240
SM00249
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5SPL2
PhosphoSite PhosphoSite-Q5SPL2
TrEMBL Q3V456
UniProt Splice Variant
Entrez Gene 268448
UniGene Mm.274329
RefSeq NP_777277
MGI ID
MGI Symbol Phf12
OMIM
CCDS CCDS48855
HPRD
IMGT
EMBL AK010807 AK129383 AK155354 AL669840 AL845484 BC043080 CH466596
GenPept AAH43080 BAC98193 BAE33212 BAE43222 CAI25223 CAI25224 CAI25700 CAI25701 EDL12901

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca