InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Flot2

Summary

InnateDB Protein

IDBP-202097.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Flot2

Protein Name

flotillin 2

Synonyms

AI573412; Esa; reggie-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000072136

InnateDB Gene

IDBG-202091 (Flot2)

Protein Structure

UniProt Annotation

Function

May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.

Subcellular Localization

Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Membrane, caveola {ECO:0000250}; Peripheral membrane protein {ECO:0000269PubMed:9153235}. Endosome {ECO:0000250}. Note=Membrane-associated protein of caveolae. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in many tissues, including suprabasal epidermis, hair follicles, heart, lung, thymus, spleen, liver, kidney and brain. Not expressed in skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005515	protein binding
GO:0035255	ionotropic glutamate receptor binding

Biological Process

GO:0007155	cell adhesion
GO:0010629	negative regulation of gene expression
GO:0050821	protein stabilization
GO:0090002	establishment of protein localization to plasma membrane
GO:1902992	negative regulation of amyloid precursor protein catabolic process

Cellular Component

GO:0002080	acrosomal membrane
GO:0005768	endosome
GO:0005901	caveola
GO:0016020	membrane
GO:0016600	flotillin complex
GO:0030139	endocytic vesicle
GO:0031982	vesicle
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome