InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Crcp

Summary

InnateDB Protein

IDBP-202211.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Crcp

Protein Name

calcitonin gene-related peptide-receptor component protein

Synonyms

AL022669;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026608

InnateDB Gene

IDBG-202209 (Crcp)

Protein Structure

UniProt Annotation

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa- B through the RIG-I pathway (By similarity). {ECO:0000250}.Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues.

Subcellular Localization

Nucleus {ECO:0000250}. Cell membrane {ECO:0000269PubMed:10903324}; Peripheral membrane protein {ECO:0000269PubMed:10903324}; Cytoplasmic side {ECO:0000269PubMed:10903324}.

Disease Associations

Tissue Specificity

Ubiquitous. Most prevalent in testis. {ECO:0000269PubMed:10067875}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0001635	calcitonin gene-related polypeptide receptor activity
GO:0003824	catalytic activity
GO:0003899	DNA-directed RNA polymerase activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006383	transcription from RNA polymerase III promoter
GO:0007218	neuropeptide signaling pathway
GO:0044237	cellular metabolic process
GO:0045087	innate immune response
GO:0051607	defense response to virus