InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: F5

Summary

InnateDB Protein

IDBP-202375.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Protein Name

coagulation factor V

Synonyms

AI173222; Cf-5; Cf5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000083204

InnateDB Gene

IDBG-202373 (F5)

Protein Structure

UniProt Annotation

Function

Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004252	serine-type endopeptidase activity
GO:0005507	copper ion binding
GO:0005515	protein binding

Biological Process

GO:0006508	proteolysis
GO:0007155	cell adhesion
GO:0007596	blood coagulation
GO:0008015	blood circulation

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0031091	platelet alpha granule

Protein Structure and Domains

PDB ID

MGI:88382

InterPro

IPR000421 Coagulation factor 5/8 C-terminal type domain
IPR008972 Cupredoxin
IPR008979 Galactose-binding domain-like
IPR009271 Coagulation factor V, LSPD
IPR011707 Multicopper oxidase, type 3

PFAM

PF00754
PF06049
PF07732

PRINTS

PIRSF

SMART

SM00231

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O88783