Mus musculus Gene: F5
Summary
InnateDB Gene IDBG-202373.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol F5
Gene Name coagulation factor V
Synonyms AI173222; Cf-5; Cf5;
Species Mus musculus
Ensembl Gene ENSMUSG00000026579
Encoded Proteins
coagulation factor V
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198734:
This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:164151838-164220277
Strand Forward strand
Band H2.2
Transcripts
ENSMUST00000086040 ENSMUSP00000083204
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004252 serine-type endopeptidase activity
GO:0005507 copper ion binding
GO:0005515 protein binding
Biological Process
GO:0006508 proteolysis
GO:0007155 cell adhesion
GO:0007596 blood coagulation
GO:0008015 blood circulation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0031091 platelet alpha granule
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Platelet degranulation pathway
Hemostasis pathway
Platelet activation, signaling and aggregation pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
Response to elevated platelet cytosolic Ca2+ pathway
Common Pathway pathway
KEGG
Complement and coagulation cascades pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Formation of Fibrin Clot (Clotting Cascade) pathway
Platelet degranulation pathway
Platelet activation, signaling and aggregation pathway
Common Pathway pathway
Response to elevated platelet cytosolic Ca2+ pathway
Hemostasis pathway
KEGG
Complement and coagulation cascades pathway
INOH
PID BIOCARTA
Extrinsic prothrombin activation pathway [Biocarta view]
Intrinsic prothrombin activation pathway [Biocarta view]
PID NCI
Cross-References
SwissProt O88783
TrEMBL Q8C7H9
UniProt Splice Variant
Entrez Gene 14067
UniGene Mm.12900
RefSeq NM_007976
OMIM
CCDS CCDS35754
HPRD
IMGT
MGI ID MGI:88382
MGI Symbol F5
EMBL AK050205 AK137521 AK139240 U52925
GenPept AAC99553 BAC34121 BAE23393 BAE23928
RNA Seq Atlas 14067