InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lrrfip2

Summary

InnateDB Protein

IDBP-202694.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lrrfip2

Protein Name

leucine rich repeat (in FLII) interacting protein 2

Synonyms

5133400F20Rik; AI850587;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000095944

InnateDB Gene

IDBG-202692 (Lrrfip2)

Protein Structure

UniProt Annotation

Function

May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta- catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0016055	Wnt signaling pathway
GO:0045087	innate immune response (InnateDB)

Cellular Component

Protein Structure and Domains

PDB ID

MGI:1918518

InterPro

IPR009053 Prefoldin
IPR019139 Leucine-rich repeat flightless-interacting protein

PFAM

PF09738

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q91WK0

PhosphoSite

PhosphoSite-Q91WK0

TrEMBL

UniProt Splice Variant

Entrez Gene

71268

UniGene

Mm.302287

RefSeq

NP_082018

MGI ID

MGI Symbol

Lrrfip2

OMIM

CCDS

CCDS23583

HPRD

IMGT

EMBL

AK017217 AK078881 BC014761

GenPept

AAH14761 BAB30640 BAC37441