InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: B2m

Summary

InnateDB Protein

IDBP-202738.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

B2m

Protein Name

beta-2 microglobulin

Synonyms

beta2-m; beta2m; Ly-m11;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099534

InnateDB Gene

IDBG-202736 (B2m)

Protein Structure

UniProt Annotation

Function

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	63 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0001895	retina homeostasis
GO:0001916	positive regulation of T cell mediated cytotoxicity
GO:0002237	response to molecule of bacterial origin
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002481	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
GO:0006968	cellular defense response
GO:0033077	T cell differentiation in thymus
GO:0042026	protein refolding
GO:0042493	response to drug
GO:0046686	response to cadmium ion

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0030670	phagocytic vesicle membrane
GO:0042612	MHC class I protein complex
GO:0070062	extracellular vesicular exosome