Version 5.4
Mus musculus Gene: B2m
Summary
InnateDB Gene IDBG-202736.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol B2m
Gene Name beta-2 microglobulin
Synonyms beta2-m; beta2m; Ly-m11
Species Mus musculus
Ensembl Gene ENSMUSG00000060802
Encoded Proteins
IDBP-202738
beta-2 microglobulin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166710:
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Sep 2009]
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:122147686-122153083
Strand Forward strand
Band E5
Transcripts
ENSMUST00000102476 ENSMUSP00000099534
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 63 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0001895 retina homeostasis
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0002237 response to molecule of bacterial origin
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002481 antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
GO:0006968 cellular defense response
GO:0033077 T cell differentiation in thymus
GO:0042026 protein refolding
GO:0042493 response to drug
GO:0046686 response to cadmium ion
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0030670 phagocytic vesicle membrane
GO:0042612 MHC class I protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000166710
View Gene Order
ENSBTAG00000012330
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_189085
Disease pathway
REACT_198563
Amyloids pathway
REACT_202937
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_230745
Immune System pathway
REACT_199105
ER-Phagosome pathway pathway
REACT_199112
Endosomal/Vacuolar pathway pathway
REACT_198660
Interferon gamma signaling pathway
REACT_198666
Interferon Signaling pathway
REACT_199113
Antigen processing-Cross presentation pathway
REACT_229531
Adaptive Immune System pathway
REACT_188188
DAP12 interactions pathway
REACT_188185
DAP12 signaling pathway
REACT_246972
Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway
KEGG
mmu04612
Antigen processing and presentation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75795
Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway
REACT_111168
Endosomal/Vacuolar pathway pathway
REACT_111178
ER-Phagosome pathway pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_25078
Interferon gamma signaling pathway
REACT_11103
Nef mediated downregulation of MHC class I complex cell surface expression pathway
REACT_75925
Amyloids pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_6802
Innate Immune System pathway
REACT_25229
Interferon Signaling pathway
REACT_11149
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway
REACT_111119
Antigen processing-Cross presentation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_6185
HIV Infection pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_6835
The role of Nef in HIV-1 replication and disease pathogenesis pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_116125
Disease pathway
REACT_217956
DAP12 interactions pathway
REACT_206540
Amyloids pathway
REACT_218212
Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway
REACT_212672
Class I MHC mediated antigen processing & presentation pathway
REACT_213138
Immune System pathway
REACT_214469
Adaptive Immune System pathway
REACT_216714
Innate Immune System pathway
REACT_214988
DAP12 signaling pathway
REACT_207087
Disease pathway
KEGG
hsa04612
Antigen processing and presentation pathway
INOH
PID NCI
cd8tcrpathway
TCR signaling in naïve CD8+ T cells
cd8tcrdownstreampathway
Downstream signaling in naïve CD8+ T cells
il12_2pathway
IL12-mediated signaling events
Cross-References
SwissProt P01887
TrEMBL
UniProt Splice Variant
Entrez Gene 12010
UniGene Mm.437261
RefSeq NM_009735
OMIM
CCDS CCDS16654
HPRD
IMGT
MGI ID MGI:88127
MGI Symbol B2m
EMBL AK019389 AK028378 AK166067 AL845457 BC085164 CH466519 M10389 M10416 M12485 M84363 M84364 M84365 M84366 M84367 X01838
GenPept AAA39536 AAA39537 AAA39667 AAA39668 AAA39669 AAA39670 AAA39671 AAH85164 BAB31695 BAC25917 BAE38551 CAA25970 CAM21783 EDL28084
RNA Seq Atlas 12010

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca