InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cd247

Summary

InnateDB Protein

IDBP-202779.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd247

Protein Name

CD247 antigen

Synonyms

4930549J05Rik; A430104F18Rik; AW552088; Cd3; Cd3-eta; Cd3-zeta; Cd3h; Cd3z; Cd3zeta; T3z; Tcrk; Tcrz;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000005907

InnateDB Gene

IDBG-202777 (Cd247)

Protein Structure

UniProt Annotation

Function

Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	14 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0050852	T cell receptor signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042105	alpha-beta T cell receptor complex

Protein Structure and Domains

PDB ID

MGI:88334

InterPro

IPR003110 Phosphorylated immunoreceptor signalling ITAM
IPR021663 T-cell surface glycoprotein CD3 zeta/eta subunit/High affinity IgE receptor gamma subunit

PFAM

PF02189
PF11628

PRINTS

PIRSF

SMART

SM00077

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P24161