InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDKN1B

Summary

InnateDB Protein

IDBP-20319.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDKN1B

Protein Name

cyclin-dependent kinase inhibitor 1B (p27, Kip1)

Synonyms

CDKN4; KIP1; MEN1B; MEN4; P27KIP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000228872

InnateDB Gene

IDBG-20317 (CDKN1B)

Protein Structure

UniProt Annotation

Function

Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1- CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. {ECO:0000269PubMed:10831586, ECO:0000269PubMed:12244301, ECO:0000269PubMed:16782892, ECO:0000269PubMed:17254966, ECO:0000269PubMed:19075005}.

Subcellular Localization

Nucleus. Cytoplasm. Endosome {ECO:0000250}. Note=Nuclear and cytoplasmic in quiescent cells. AKT- or RSK- mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen- activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89. Colocalizes at the endosome with SNX6; this leads to lysosomal degradation (By similarity). {ECO:0000250}.

Disease Associations

Multiple endocrine neoplasia 4 (MEN4) [MIM:610755]: Multiple endocrine neoplasia (MEN) syndromes are inherited cancer syndromes of the thyroid. MEN4 is a MEN-like syndrome with a phenotypic overlap of both MEN1 and MEN2. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 157 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	157 [view]
Protein-Protein	145 [view]
Protein-DNA	11 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity
GO:0005515	protein binding
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0019903	protein phosphatase binding
GO:0030544	Hsp70 protein binding
GO:0032403	protein complex binding
GO:0051087	chaperone binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0001666	response to hypoxia
GO:0006813	potassium ion transport
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007050	cell cycle arrest
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007605	sensory perception of sound
GO:0008219	cell death
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009749	response to glucose
GO:0010942	positive regulation of cell death
GO:0014070	response to organic cyclic compound
GO:0030308	negative regulation of cell growth
GO:0031116	positive regulation of microtubule polymerization
GO:0032355	response to estradiol
GO:0033673	negative regulation of kinase activity
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042326	negative regulation of phosphorylation
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process
GO:0043200	response to amino acid
GO:0043434	response to peptide hormone
GO:0045087	innate immune response
GO:0045732	positive regulation of protein catabolic process
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045930	negative regulation of mitotic cell cycle
GO:0046686	response to cadmium ion
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0048102	autophagic cell death
GO:0048839	inner ear development
GO:0050680	negative regulation of epithelial cell proliferation
GO:0051271	negative regulation of cellular component movement
GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0071236	cellular response to antibiotic
GO:0071285	cellular response to lithium ion
GO:0071407	cellular response to organic cyclic compound
GO:0071850	mitotic cell cycle arrest