InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hspb1

Summary

InnateDB Protein

IDBP-204153.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hspb1

Protein Name

heat shock protein 1

Synonyms

27kDa; Hsp25;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000005077

InnateDB Gene

IDBG-204151 (Hspb1)

Protein Structure

UniProt Annotation

Function

Involved in stress resistance and actin organization.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 92 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	92 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0008426	protein kinase C inhibitor activity
GO:0019901	protein kinase binding
GO:0042802	identical protein binding
GO:0043130	ubiquitin binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001895	retina homeostasis
GO:0006469	negative regulation of protein kinase activity
GO:0006986	response to unfolded protein
GO:0009615	response to virus
GO:0032731	positive regulation of interleukin-1 beta production
GO:0035556	intracellular signal transduction
GO:0035924	cellular response to vascular endothelial growth factor stimulus
GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process
GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043536	positive regulation of blood vessel endothelial cell migration
GO:0045766	positive regulation of angiogenesis
GO:0071901	negative regulation of protein serine/threonine kinase activity
GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:2001028	positive regulation of endothelial cell chemotaxis
GO:2001234	negative regulation of apoptotic signaling pathway

Cellular Component

GO:0000502	proteasome complex
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0005886	plasma membrane
GO:0030018	Z disc
GO:0043292	contractile fiber
GO:0070062	extracellular vesicular exosome