InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdk5r1

Summary

InnateDB Protein

IDBP-204313.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdk5r1

Protein Name

cyclin-dependent kinase 5, regulatory subunit 1 (p35)

Synonyms

Cdk5r; D11Bwg0379e; p25; p35;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099514

InnateDB Gene

IDBG-204311 (Cdk5r1)

Protein Structure

UniProt Annotation

Function

p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. {ECO:0000269PubMed:17143272, ECO:0000269PubMed:24235147}.

Subcellular Localization

Cyclin-dependent kinase 5 activator 1, p35: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}.Cyclin-dependent kinase 5 activator 1, p25: Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=The conversion of p35 to p25 relocalizes the protein from the cell periphery to the cytoplasm, in nuclear and perinuclear regions. {ECO:0000250}.

Disease Associations

Tissue Specificity

Brain and neuron specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004693	cyclin-dependent protein serine/threonine kinase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0016301	kinase activity
GO:0016534	cyclin-dependent protein kinase 5 activator activity
GO:0019901	protein kinase binding
GO:0043539	protein serine/threonine kinase activator activity
GO:0045296	cadherin binding
GO:0046875	ephrin receptor binding

Biological Process

GO:0001764	neuron migration
GO:0006468	protein phosphorylation
GO:0007049	cell cycle
GO:0007158	neuron cell-cell adhesion
GO:0007213	G-protein coupled acetylcholine receptor signaling pathway
GO:0007411	axon guidance
GO:0007413	axonal fasciculation
GO:0007420	brain development
GO:0009790	embryo development
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0021549	cerebellum development
GO:0021722	superior olivary nucleus maturation
GO:0021766	hippocampus development
GO:0021799	cerebral cortex radially oriented cell migration
GO:0021819	layer formation in cerebral cortex
GO:0030182	neuron differentiation
GO:0030517	negative regulation of axon extension
GO:0031175	neuron projection development
GO:0032956	regulation of actin cytoskeleton organization
GO:0033136	serine phosphorylation of STAT3 protein
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0043525	positive regulation of neuron apoptotic process
GO:0045860	positive regulation of protein kinase activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048013	ephrin receptor signaling pathway
GO:0048511	rhythmic process
GO:0051726	regulation of cell cycle
GO:0061001	regulation of dendritic spine morphogenesis
GO:0070507	regulation of microtubule cytoskeleton organization
GO:0071902	positive regulation of protein serine/threonine kinase activity
GO:0090314	positive regulation of protein targeting to membrane

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex
GO:0030424	axon
GO:0030425	dendrite
GO:0030426	growth cone
GO:0031594	neuromuscular junction
GO:0043025	neuronal cell body
GO:0043197	dendritic spine
GO:0043292	contractile fiber
GO:0048471	perinuclear region of cytoplasm