InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cckbr

Summary

InnateDB Protein

IDBP-204680.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cckbr

Protein Name

cholecystokinin B receptor

Synonyms

CCK2R; CCKR-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033189

InnateDB Gene

IDBG-204676 (Cckbr)

Protein Structure

UniProt Annotation

Function

Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0015054	gastrin receptor activity
GO:0031741	type B gastrin/cholecystokinin receptor binding

Biological Process

GO:0001696	gastric acid secretion
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0008284	positive regulation of cell proliferation
GO:0048565	digestive tract development
GO:0048732	gland development

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:99479

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000314 Gastrin receptor
IPR000611 Neuropeptide Y receptor family
IPR009126 Cholecystokinin receptor
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00237
PR00527
PR01012
PR01822

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P56481