InnateDB Protein
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IDBP-204765.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Hpx
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Protein Name
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hemopexin
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Synonyms
|
Hpxn; hx;
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Species
|
Mus musculus
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Ensembl Protein
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ENSMUSP00000033185
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InnateDB Gene
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IDBG-204763 (Hpx)
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Protein Structure
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|
Function |
Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
Expressed by the liver and secreted in plasma.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated |
Total |
9
[view]
|
Protein-Protein |
9
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
|
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Predicted by orthology |
Total |
7 [view]
|
|
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Molecular Function |
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Biological Process |
GO:0002639
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positive regulation of immunoglobulin production
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GO:0002925
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positive regulation of humoral immune response mediated by circulating immunoglobulin
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GO:0006810
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transport
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GO:0020027
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hemoglobin metabolic process
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GO:0042168
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heme metabolic process
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GO:0042511
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positive regulation of tyrosine phosphorylation of Stat1 protein
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GO:0051246
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regulation of protein metabolic process
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GO:0060332
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positive regulation of response to interferon-gamma
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GO:0060335
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positive regulation of interferon-gamma-mediated signaling pathway
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Cellular Component |
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PDB ID |
MGI:105112
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InterPro |
IPR000585
Hemopexin-like domain
IPR016358
Hemopexin, chordata
IPR018487
Hemopexin-like repeats
|
PFAM |
PF00045
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PRINTS |
|
PIRSF |
PIRSF002551
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SMART |
SM00120
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TIGRFAMs |
|
Modification |
|
SwissProt |
Q91X72
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PhosphoSite |
PhosphoSite-Q91X72
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TrEMBL |
|
UniProt Splice Variant |
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Entrez Gene |
15458
|
UniGene |
Mm.3485
|
RefSeq |
NP_059067
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MGI ID |
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MGI Symbol |
Hpx
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OMIM |
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CCDS |
CCDS21654
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HPRD |
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IMGT |
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EMBL |
AK145928
BC011246
BC019901
CH466531
U89889
|
GenPept |
AAB49490
AAH11246
AAH19901
BAE26759
EDL16785
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