Version 5.4
Mus musculus Gene: Hpx
Summary
InnateDB Gene IDBG-204763.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hpx
Gene Name hemopexin
Synonyms Hpxn; hx
Species Mus musculus
Ensembl Gene ENSMUSG00000030895
Encoded Proteins
IDBP-204765
hemopexin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110169:
This gene encodes a plasma glycoprotein that binds heme with high affinity. The encoded protein is an acute phase protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative stress. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:105591613-105600116
Strand Reverse strand
Band E3
Transcripts
ENSMUST00000033185 ENSMUSP00000033185
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0002639 positive regulation of immunoglobulin production
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0006810 transport
GO:0020027 hemoglobin metabolic process
GO:0042168 heme metabolic process
GO:0042511 positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0051246 regulation of protein metabolic process
GO:0060332 positive regulation of response to interferon-gamma
GO:0060335 positive regulation of interferon-gamma-mediated signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000110169
View Gene Order
ENSBTAG00000003564
Not yet available
Pathways
NETPATH
REACTOME
REACT_196575
Scavenging of heme from plasma pathway
REACT_196573
Binding and Uptake of Ligands by Scavenger Receptors pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160163
Scavenging of heme from plasma pathway
REACT_160300
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_213817
Binding and Uptake of Ligands by Scavenger Receptors pathway
REACT_219679
Scavenging of heme from plasma pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q91X72
TrEMBL
UniProt Splice Variant
Entrez Gene 15458
UniGene Mm.3485
RefSeq NM_017371
OMIM
CCDS CCDS21654
HPRD
IMGT
MGI ID MGI:105112
MGI Symbol Hpx
EMBL AK145928 BC011246 BC019901 CH466531 U89889
GenPept AAB49490 AAH11246 AAH19901 BAE26759 EDL16785
RNA Seq Atlas 15458

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca