InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dffa

Summary

InnateDB Protein

IDBP-204898.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dffa

Protein Name

DNA fragmentation factor, alpha subunit

Synonyms

A330085O09Rik; DFF35; Dff45; ICAD; ICAD-L; ICAD-S;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030816

InnateDB Gene

IDBG-204894 (Dffa)

Protein Structure

UniProt Annotation

Function

Inhibitor of the caspase-activated DNase (DFF40).

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006309	apoptotic DNA fragmentation
GO:0006915	apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0070242	thymocyte apoptotic process
GO:1900118	negative regulation of execution phase of apoptosis
GO:1902511	negative regulation of apoptotic DNA fragmentation

Cellular Component

GO:0000790	nuclear chromatin
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:1196227

InterPro

IPR003508 CIDE-N domain
IPR015121 DNA fragmentation factor 45kDa, middle domain
IPR017299 DNA fragmentation factor, alpha subunit
IPR027296 DNA fragmentation factor 45kDa C-terminal domain

PFAM

PF02017
PF09033

PRINTS

PIRSF

PIRSF037865

SMART

SM00266

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt