InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FST

Summary

InnateDB Protein

IDBP-20492.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FST

Protein Name

follistatin

Synonyms

FS;

Species

Homo sapiens

Ensembl Protein

ENSP00000256759

InnateDB Gene

IDBG-20490 (FST)

Protein Structure

UniProt Annotation

Function

Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid. {ECO:0000269PubMed:15472207}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	16 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0043395	heparan sulfate proteoglycan binding
GO:0048185	activin binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001501	skeletal system development
GO:0002244	hematopoietic progenitor cell differentiation
GO:0007276	gamete generation
GO:0007389	pattern specification process
GO:0008585	female gonad development
GO:0030509	BMP signaling pathway
GO:0031069	hair follicle morphogenesis
GO:0032926	negative regulation of activin receptor signaling pathway
GO:0042475	odontogenesis of dentin-containing tooth
GO:0043616	keratinocyte proliferation
GO:0045596	negative regulation of cell differentiation
GO:0051798	positive regulation of hair follicle development