Homo sapiens Gene: FST
Summary
InnateDB Gene IDBG-20490.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FST
Gene Name follistatin
Synonyms FS;
Species Homo sapiens
Ensembl Gene ENSG00000134363
Encoded Proteins
follistatin
follistatin
follistatin
follistatin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008]
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:53480409-53487134
Strand Forward strand
Band q11.2
Transcripts
ENST00000256759 ENSP00000256759
ENST00000396947 ENSP00000380151
ENST00000491717
ENST00000504226 ENSP00000426315
ENST00000497789 ENSP00000426971
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 16 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0043395 heparan sulfate proteoglycan binding
GO:0048185 activin binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001501 skeletal system development
GO:0002244 hematopoietic progenitor cell differentiation
GO:0007276 gamete generation
GO:0007389 pattern specification process
GO:0008585 female gonad development
GO:0030509 BMP signaling pathway
GO:0031069 hair follicle morphogenesis
GO:0032926 negative regulation of activin receptor signaling pathway
GO:0042475 odontogenesis of dentin-containing tooth
GO:0043616 keratinocyte proliferation
GO:0045596 negative regulation of cell differentiation
GO:0051798 positive regulation of hair follicle development
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Signal Transduction pathway
Antagonism of Activin by Follistatin pathway
Signaling by Activin pathway
KEGG
TGF-beta signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
BMP receptor signaling
Cross-References
SwissProt P19883
TrEMBL
UniProt Splice Variant
Entrez Gene 10468
UniGene Hs.683607 Hs.743863 Hs.9914
RefSeq NM_006350 XM_005248403 NM_013409 XM_005248401
HUGO HGNC:3971
OMIM 136470
CCDS CCDS43315 CCDS3959
HPRD 00641
IMGT
EMBL AB451330 AB451474 BC004107 CH471123 M19480 M19481
GenPept AAA35851 AAH04107 BAG70144 BAG70288 EAW54880
RNA Seq Atlas 10468