InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ilk

Summary

InnateDB Protein

IDBP-204957.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ilk

Protein Name

integrin linked kinase

Synonyms

AA511515; ESTM24;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033182

InnateDB Gene

IDBG-204955 (Ilk)

Protein Structure

UniProt Annotation

Function

Receptor-proximal protein kinase regulating integrin- mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B (By similarity). {ECO:0000250}.

Subcellular Localization

Cell junction, focal adhesion. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, myofibril, sarcomere {ECO:0000250}. Cell projection, lamellipodium.

Disease Associations

Tissue Specificity

Highly expressed in lung, heart, kidney, liver, brain, spleen and skeletal muscle. Weakly expressed in testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 91 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	91 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004871	signal transducer activity
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017124	SH3 domain binding
GO:0019901	protein kinase binding

Biological Process

GO:0001558	regulation of cell growth
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001954	positive regulation of cell-matrix adhesion
GO:0006468	protein phosphorylation
GO:0006469	negative regulation of protein kinase activity
GO:0007050	cell cycle arrest
GO:0007229	integrin-mediated signaling pathway
GO:0007569	cell aging
GO:0008284	positive regulation of cell proliferation
GO:0009966	regulation of signal transduction
GO:0010667	negative regulation of cardiac muscle cell apoptotic process
GO:0010761	fibroblast migration
GO:0014044	Schwann cell development
GO:0014912	negative regulation of smooth muscle cell migration
GO:0018105	peptidyl-serine phosphorylation
GO:0021675	nerve development
GO:0022011	myelination in peripheral nervous system
GO:0030030	cell projection organization
GO:0030335	positive regulation of cell migration
GO:0030513	positive regulation of BMP signaling pathway
GO:0032288	myelin assembly
GO:0032956	regulation of actin cytoskeleton organization
GO:0034446	substrate adhesion-dependent cell spreading
GO:0042327	positive regulation of phosphorylation
GO:0043066	negative regulation of apoptotic process
GO:0043206	extracellular fibril organization
GO:0043406	positive regulation of MAP kinase activity
GO:0043410	positive regulation of MAPK cascade
GO:0043491	protein kinase B signaling
GO:0043524	negative regulation of neuron apoptotic process
GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity
GO:0045663	positive regulation of myoblast differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045773	positive regulation of axon extension
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0048812	neuron projection morphogenesis
GO:0050772	positive regulation of axonogenesis
GO:0050775	positive regulation of dendrite morphogenesis
GO:0051291	protein heterooligomerization
GO:0051897	positive regulation of protein kinase B signaling
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:2000178	negative regulation of neural precursor cell proliferation

Cellular Component

GO:0001725	stress fiber
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0030017	sarcomere
GO:0030027	lamellipodium
GO:0030054	cell junction
GO:0030424	axon
GO:0043025	neuronal cell body
GO:0043034	costamere
GO:0043195	terminal bouton
GO:0043198	dendritic shaft
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

MGI:1195267

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002110 Ankyrin repeat
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR016253 Integrin-linked protein kinase
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR020683 Ankyrin repeat-containing domain

PFAM

PF00069
PF07714
PF00023
PF13606
PF11929
PF12796

PRINTS

PR00109
PR01415

PIRSF

PIRSF000654

SMART

SM00248
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References