InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mal

Summary

InnateDB Protein

IDBP-205038.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mal

Protein Name

myelin and lymphocyte protein, T-cell differentiation protein

Synonyms

Mpv17; Vip17;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028853

InnateDB Gene

IDBG-205036 (Mal)

Protein Structure

UniProt Annotation

Function

Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Plays a role in the maintenance of the myelin sheath and in axon- glia and glia-glia interactions. {ECO:0000269PubMed:15337780}.

Subcellular Localization

Golgi apparatus membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Found in lipid raft.

Disease Associations

Tissue Specificity

Expressed in the spinal cord, brain, kidney and gastrointestinal tract especially in the stomach and caecum. Highly expressed by myelinating glial cells. {ECO:0000269PubMed:15337780}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0019911	structural constituent of myelin sheath

Biological Process

GO:0042552	myelination
GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

Cellular Component

GO:0000139	Golgi membrane
GO:0005783	endoplasmic reticulum
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0019898	extrinsic component of membrane
GO:0045121	membrane raft