Version 5.4
Mus musculus Gene: Mal
Summary
InnateDB Gene IDBG-205036.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mal
Gene Name myelin and lymphocyte protein, T cell differentiation protein
Synonyms Mpv17; Vip17
Species Mus musculus
Ensembl Gene ENSMUSG00000027375
Encoded Proteins
IDBP-205038
myelin and lymphocyte protein, T-cell differentiation protein
IDBP-205040
myelin and lymphocyte protein, T-cell differentiation protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The encoded protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:127633226-127656695
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000028853 ENSMUSP00000028853
ENSMUST00000028854 ENSMUSP00000028854
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019911 structural constituent of myelin sheath
Biological Process
GO:0042552 myelination
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0019898 extrinsic component of membrane
GO:0045121 membrane raft
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000172005
View Gene Order
ENSBTAG00000034586
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt O09198
TrEMBL
UniProt Splice Variant
Entrez Gene 17153
UniGene Mm.39040 Mm.474422
RefSeq NM_010762 NM_001171187
OMIM
CCDS CCDS16707 CCDS50705
HPRD
IMGT
MGI ID MGI:892970
MGI Symbol Mal
EMBL AK004639 AK019046 AK158653 AK169172 AL731831 AL844204 BC006826 Y07626 Y07627 Y07628 Y07629 Y07630 Y07812
GenPept AAH06826 BAB23430 BAB31523 BAE34599 BAE40951 CAA68907 CAA68908 CAA69143 CAM13438 CAM13439 CAM16966 CAM16967
RNA Seq Atlas 17153

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca