InnateDB Protein
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IDBP-20578.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HOOK3
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Protein Name
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hook homolog 3 (Drosophila)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000305699
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InnateDB Gene
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IDBG-20576 (HOOK3)
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Protein Structure
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Function |
Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. {ECO:0000250, ECO:0000269PubMed:11238449, ECO:0000269PubMed:17237231, ECO:0000269PubMed:18799622}.
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Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000269PubMed:11238449}. Golgi apparatus {ECO:0000269PubMed:11238449}. Note=Enriched at the cis-face of the Golgi complex. Localizes to microtubule asters in prophase. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
15
[view]
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Protein-Protein |
14
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR008636
Hook-related protein family
IPR010989
t-SNARE
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PFAM |
PF05622
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q86VS8
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PhosphoSite |
PhosphoSite-Q86VS8
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
84376
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UniGene |
Hs.731309
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RefSeq |
NP_115786
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HUGO |
HGNC:23576
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OMIM |
607825
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CCDS |
CCDS6139
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HPRD |
09699
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IMGT |
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EMBL |
AF241830
AK090540
BC048304
BC056146
CH471080
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GenPept |
AAH48304
AAH56146
AAK29204
BAC03473
EAW63197
EAW63198
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