Homo sapiens Gene: HOOK3
Summary
InnateDB Gene IDBG-20576.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HOOK3
Gene Name hook homolog 3 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000168172
Encoded Proteins
hook homolog 3 (Drosophila)
hook homolog 3 (Drosophila)
hook homolog 3 (Drosophila)
hook homolog 3 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:42896932-43030539
Strand Forward strand
Band p11.21
Transcripts
ENST00000307602 ENSP00000305699
ENST00000527306
ENST00000526882 ENSP00000435077
ENST00000533539 ENSP00000433953
ENST00000524839
ENST00000533338 ENSP00000433813
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0042802 identical protein binding
Biological Process
GO:0007032 endosome organization
GO:0007040 lysosome organization
GO:0008333 endosome to lysosome transport
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0022027 interkinetic nuclear migration
GO:0031122 cytoplasmic microtubule organization
GO:0034454 microtubule anchoring at centrosome
GO:0045022 early endosome to late endosome transport
GO:0050768 negative regulation of neurogenesis
GO:0051645 Golgi localization
GO:0071539 protein localization to centrosome
GO:0097150 neuronal stem cell maintenance
Cellular Component
GO:0000242 pericentriolar material
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005801 cis-Golgi network
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005874 microtubule
GO:0016020 membrane
GO:0030897 HOPS complex
GO:0034451 centriolar satellite
GO:0070695 FHF complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt Q86VS8
TrEMBL
UniProt Splice Variant
Entrez Gene 84376
UniGene Hs.162852 Hs.614207 Hs.731309
RefSeq NM_032410
HUGO HGNC:23576
OMIM 607825
CCDS CCDS6139
HPRD 09699
IMGT
EMBL AF241830 AK090540 BC048304 BC056146 CH471080
GenPept AAH48304 AAH56146 AAK29204 BAC03473 EAW63197 EAW63198
RNA Seq Atlas 84376