Version 5.4
Homo sapiens Gene: HOOK3
Summary
InnateDB Gene IDBG-20576.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HOOK3
Gene Name hook homolog 3 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000168172
Encoded Proteins
IDBP-20578
hook homolog 3 (Drosophila)
IDBP-597459
hook homolog 3 (Drosophila)
IDBP-590701
hook homolog 3 (Drosophila)
IDBP-589989
hook homolog 3 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:42896932-43030539
Strand Forward strand
Band p11.21
Transcripts
ENST00000307602 ENSP00000305699
ENST00000527306
ENST00000526882 ENSP00000435077
ENST00000533539 ENSP00000433953
ENST00000524839
ENST00000533338 ENSP00000433813
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0042802 identical protein binding
Biological Process
GO:0007032 endosome organization
GO:0007040 lysosome organization
GO:0008333 endosome to lysosome transport
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0022027 interkinetic nuclear migration
GO:0031122 cytoplasmic microtubule organization
GO:0034454 microtubule anchoring at centrosome
GO:0045022 early endosome to late endosome transport
GO:0050768 negative regulation of neurogenesis
GO:0051645 Golgi localization
GO:0071539 protein localization to centrosome
GO:0097150 neuronal stem cell maintenance
Cellular Component
GO:0000242 pericentriolar material
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005801 cis-Golgi network
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005874 microtubule
GO:0016020 membrane
GO:0030897 HOPS complex
GO:0034451 centriolar satellite
GO:0070695 FHF complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037234
View Gene Order
ENSBTAG00000007634
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.162852 Hs.614207 Hs.731309
RefSeq NM_032410
HUGO
OMIM
CCDS CCDS6139
HPRD 09699
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca