Version 5.4
Homo sapiens Protein: SLC7A1
Summary
InnateDB Protein IDBP-20595.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC7A1
Protein Name solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
Synonyms ATRC1; CAT-1; ERR; HCAT1; REC1L;
Species Homo sapiens
Ensembl Protein ENSP00000370128
InnateDB Gene IDBG-20593 (SLC7A1)
Protein Structure
UniProt Annotation
Function High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. May also function as an ecotropic retroviral leukemia receptor.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Ubiquitous.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 3 [view]
Protein-DNA 2 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0015171 amino acid transmembrane transporter activity
GO:0015181 arginine transmembrane transporter activity
Biological Process
GO:0003333 amino acid transmembrane transport
GO:0006810 transport
GO:0006811 ion transport
GO:0006865 amino acid transport
GO:0015809 arginine transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR002293 Amino acid/polyamine transporter I
IPR004755 Cationic amino acid transport permease
IPR004841 Amino acid permease/ SLC12A domain
PFAM PF13520
PF00324
PRINTS
PIRSF PIRSF006060
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P30825
PhosphoSite PhosphoSite-P30825
TrEMBL Q5JR49
UniProt Splice Variant
Entrez Gene 6541
UniGene Hs.604662
RefSeq NP_003036
HUGO HGNC:11057
OMIM 104615
CCDS CCDS9333
HPRD 00091
IMGT
EMBL AF078107 AL596114 BC063303 BC069358 BC115407 CH471075 X57303 X59155
GenPept AAC27721 AAH63303 AAH69358 AAI15408 CAA40560 CAA41869 CAI39913 EAX08443 EAX08444

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca