InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nlrp10

Summary

InnateDB Protein

IDBP-205993.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nlrp10

Protein Name

NLR family, pyrin domain containing 10

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000050252

InnateDB Gene

IDBG-205991 (Nlrp10)

Protein Structure

UniProt Annotation

Function

Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID. Displays anti-inflammatory activity. Plays a role in adaptive immunity through control of dendritic cell-mediated transport of antigen to the lymph nodes from peripheral sites. Required for immunity against C.albicans infection. Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection. {ECO:0000269PubMed:22538615, ECO:0000269PubMed:23071280}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Cytoplasmic protein which is recruited to the cell membrane by NOD1 following invasive bacterial infection. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in skin, tongue, heart, colon and several cell lines of hematopoietic and myocytic origin but not in kidney, skeletal muscle, spleen, liver, lung, thymus, brain or small intestine (at protein level). {ECO:0000269PubMed:20393137}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0002827	positive regulation of T-helper 1 type immune response
GO:0006952	defense response
GO:0008152	metabolic process
GO:0035397	helper T cell enhancement of adaptive immune response
GO:0036336	dendritic cell migration
GO:0045087	innate immune response
GO:0050829	defense response to Gram-negative bacterium
GO:0050832	defense response to fungus
GO:2000318	positive regulation of T-helper 17 type immune response
GO:2000484	positive regulation of interleukin-8 secretion
GO:2000778	positive regulation of interleukin-6 secretion

Cellular Component

GO:0005737	cytoplasm
GO:0019897	extrinsic component of plasma membrane

Protein Structure and Domains

PDB ID

MGI:2444084

InterPro

IPR004020 DAPIN domain
IPR007111 NACHT nucleoside triphosphatase
IPR011029 Death-like domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF02758

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8CCN1

PhosphoSite