InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ascl3

Summary

InnateDB Protein

IDBP-206252.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ascl3

Protein Name

achaete-scute complex homolog 3 (Drosophila)

Synonyms

bHLHa42; Sgn1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037702

InnateDB Gene

IDBG-206250 (Ascl3)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor. Inhibits myogenesis.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Specifically expressed in the salivary duct cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0046983	protein dimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005730	nucleolus

Protein Structure and Domains

PDB ID

MGI:1928820

InterPro

IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain

PFAM

PF00010

PRINTS

PIRSF

SMART

SM00353

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JJR7

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

56787

UniGene

Mm.29275

RefSeq

NP_064435

MGI ID

MGI Symbol

Ascl3

OMIM

CCDS

CCDS21737

HPRD

IMGT

EMBL

AB046448 AJ277605 AJ400878 BC104346 BC104347

GenPept

AAI04347 AAI04348 BAB83911 CAB92296 CAC37689