InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Limd1

Summary

InnateDB Protein

IDBP-206307.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Limd1

Protein Name

LIM domains containing 1

Synonyms

AW822033; D9Ertd192e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026269

InnateDB Gene

IDBG-206305 (Limd1)

Protein Structure

UniProt Annotation

Function

Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG- dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1- responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269PubMed:17092936, ECO:0000269PubMed:18657804}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:18657804}. Nucleus {ECO:0000250}. Cytoplasm, P-body {ECO:0000250}. Cell junction, adherens junction {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Note=Shuttles between cytoplasm and nucleus but is localized predominantly to the cytoplasm. Found in the nucleus but not nucleoli. Colocalizes with VCL in the focal adhesions (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:10647888}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0001666	response to hypoxia
GO:0002076	osteoblast development
GO:0006351	transcription, DNA-templated
GO:0007010	cytoskeleton organization
GO:0008360	regulation of cell shape
GO:0016310	phosphorylation
GO:0016477	cell migration
GO:0033962	cytoplasmic mRNA processing body assembly
GO:0035195	gene silencing by miRNA
GO:0035331	negative regulation of hippo signaling
GO:0045668	negative regulation of osteoblast differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:2000637	positive regulation of gene silencing by miRNA

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005912	adherens junction
GO:0005925	focal adhesion
GO:0016442	RISC complex