InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Espn

Summary

InnateDB Protein

IDBP-206388.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Espn

Protein Name

espin

Synonyms

je;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030785

InnateDB Gene

IDBG-206386 (Espn)

Protein Structure

UniProt Annotation

Function

Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimensions, dynamics and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in variouS mechanosensory and chemosensory cells. {ECO:0000269PubMed:14657236, ECO:0000269PubMed:15190118}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cell projection, stereocilium. Cell projection, microvillus. Cell junction.Isoform 2: Cytoplasm, cytoskeleton. Cell projection, dendritic spine.Isoform 3: Cytoplasm, cytoskeleton. Cell projection, dendritic spine.Isoform 4: Cytoplasm, cytoskeleton. Cell projection, dendritic spine.Isoform 5: Cytoplasm, cytoskeleton. Cell projection, dendritic spine.Isoform 8: Cytoplasm, cytoskeleton. Cell junction. Note=Isoform 8 localizes to parallel actin bundles of ectoplasmic specializations between neighboring Sertoli cells and at sites where Sertoli cells contact the heads of elongate spermatids.

Disease Associations

Tissue Specificity

Expressed at high concentration in the microvillar parallel actin bundle (PAB) of hair cells stereocilia in the cochlea and vestibular system. Detected also at high levels of a number of other sensory cell types, including taste receptor cells, solitary chemoreceptor cells, vomeronasal sensory neurons and Merkel cells. Isoforms 2, 3, 4 and 5 are expressed in Purkinje cells dentritic spines. {ECO:0000269PubMed:10975527, ECO:0000269PubMed:12598619, ECO:0000269PubMed:15190118}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0051015	actin filament binding

Biological Process

GO:0007605	sensory perception of sound
GO:0007626	locomotory behavior
GO:0030046	parallel actin filament bundle assembly
GO:0051017	actin filament bundle assembly
GO:0051491	positive regulation of filopodium assembly
GO:0051494	negative regulation of cytoskeleton organization
GO:0051639	actin filament network formation

Cellular Component

GO:0005737	cytoplasm
GO:0005903	brush border
GO:0015629	actin cytoskeleton
GO:0030054	cell junction
GO:0031941	filamentous actin
GO:0032420	stereocilium
GO:0032421	stereocilium bundle
GO:0032426	stereocilium bundle tip
GO:0043197	dendritic spine