Version 5.4
Mus musculus Gene: Espn
Summary
InnateDB Gene IDBG-206386.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Espn
Gene Name espin
Synonyms je
Species Mus musculus
Ensembl Gene ENSMUSG00000028943
Encoded Proteins
IDBP-206388
espin
IDBP-206390
espin
IDBP-206392
espin
IDBP-206394
espin
IDBP-206396
espin
IDBP-206398
espin
IDBP-270408
espin
IDBP-270410
espin
IDBP-270412
espin
IDBP-270414
espin
IDBP-270416
espin
IDBP-270418
espin
IDBP-270420
espin
IDBP-537163
espin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000187017:
This gene encodes a multifunctional actin-bundling protein. It plays a major role in regulating the organization, dimensions, dynamics, and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in various mechanosensory and chemosensory cells. Mutations in this gene are associated with autosomal recessive neurosensory deafness, and autosomal dominant sensorineural deafness without vestibular involvement. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:152120331-152152371
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000030785 ENSMUSP00000030785
ENSMUST00000084114 ENSMUSP00000081131
ENSMUST00000070018 ENSMUSP00000065545
ENSMUST00000080042 ENSMUSP00000078951
ENSMUST00000049305 ENSMUSP00000037982
ENSMUST00000103196 ENSMUSP00000099485
ENSMUST00000105659 ENSMUSP00000101284
ENSMUST00000105658 ENSMUSP00000101283
ENSMUST00000105657 ENSMUSP00000101282
ENSMUST00000105656 ENSMUSP00000101281
ENSMUST00000105655 ENSMUSP00000101280
ENSMUST00000105654 ENSMUSP00000101279
ENSMUST00000105653 ENSMUSP00000101278
ENSMUST00000150958
ENSMUST00000136627
ENSMUST00000156517
ENSMUST00000135185 ENSMUSP00000122464
ENSMUST00000137937
ENSMUST00000148075
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0051015 actin filament binding
Biological Process
GO:0007605 sensory perception of sound
GO:0007626 locomotory behavior
GO:0030046 parallel actin filament bundle assembly
GO:0051017 actin filament bundle assembly
GO:0051491 positive regulation of filopodium assembly
GO:0051494 negative regulation of cytoskeleton organization
GO:0051639 actin filament network formation
Cellular Component
GO:0005737 cytoplasm
GO:0005903 brush border
GO:0015629 actin cytoskeleton
GO:0030054 cell junction
GO:0031941 filamentous actin
GO:0032420 stereocilium
GO:0032421 stereocilium bundle
GO:0032426 stereocilium bundle tip
GO:0043197 dendritic spine
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000187017
View Gene Order
ENSBTAG00000006515
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.264215 Mm.439374
RefSeq NM_019585 NM_207687 NM_207688 NM_207689 NM_207690 NM_207691 XM_006539063
OMIM
CCDS CCDS18989 CCDS18990 CCDS18991 CCDS18992 CCDS18993 CCDS18994
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca