InnateDB Protein
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IDBP-206392.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Espn
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Protein Name
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espin
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Synonyms
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je;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000065545
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InnateDB Gene
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IDBG-206386 (Espn)
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Protein Structure
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Function |
Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimensions, dynamics and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in variouS mechanosensory and chemosensory cells. {ECO:0000269PubMed:14657236, ECO:0000269PubMed:15190118}.
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Subcellular Localization |
Cytoplasm, cytoskeleton. Cell projection, stereocilium. Cell projection, microvillus. Cell junction.Isoform 2: Cytoplasm, cytoskeleton. Cell projection, dendritic spine.Isoform 3: Cytoplasm, cytoskeleton. Cell projection, dendritic spine.Isoform 4: Cytoplasm, cytoskeleton. Cell projection, dendritic spine.Isoform 5: Cytoplasm, cytoskeleton. Cell projection, dendritic spine.Isoform 8: Cytoplasm, cytoskeleton. Cell junction. Note=Isoform 8 localizes to parallel actin bundles of ectoplasmic specializations between neighboring Sertoli cells and at sites where Sertoli cells contact the heads of elongate spermatids.
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Disease Associations |
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Tissue Specificity |
Expressed at high concentration in the microvillar parallel actin bundle (PAB) of hair cells stereocilia in the cochlea and vestibular system. Detected also at high levels of a number of other sensory cell types, including taste receptor cells, solitary chemoreceptor cells, vomeronasal sensory neurons and Merkel cells. Isoforms 2, 3, 4 and 5 are expressed in Purkinje cells dentritic spines. {ECO:0000269PubMed:10975527, ECO:0000269PubMed:12598619, ECO:0000269PubMed:15190118}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1861630
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InterPro |
IPR003124
WH2 domain
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PFAM |
PF02205
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PRINTS |
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PIRSF |
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SMART |
SM00246
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TIGRFAMs |
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Modification |
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SwissProt |
Q9ET47
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PhosphoSite |
PhosphoSite-Q9ET47
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TrEMBL |
Q9WUH6
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UniProt Splice Variant |
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Entrez Gene |
56226
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UniGene |
Mm.439374
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RefSeq |
NP_997574
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MGI ID |
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MGI Symbol |
Espn
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OMIM |
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CCDS |
CCDS18993
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HPRD |
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IMGT |
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EMBL |
AF134857
AF134858
AF239886
AF540942
AF540943
AF540944
AF540945
AL772240
AY587570
AY587571
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GenPept |
AAD24481
AAF18322
AAF98134
AAO50326
AAO50327
AAO50328
AAO50329
AAT46472
AAT46473
CAM19680
CAM19684
CAM19685
CAM19686
CAM19687
CAM19691
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