InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Adss

Summary

InnateDB Protein

IDBP-206769.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adss

Protein Name

adenylosuccinate synthetase, non muscle

Synonyms

Adss2; AI314886; AS;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000016105

InnateDB Gene

IDBG-206767 (Adss)

Protein Structure

UniProt Annotation

Function

Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. {ECO:0000269PubMed:12482871}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004019	adenylosuccinate synthase activity
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0006164	purine nucleotide biosynthetic process
GO:0006167	AMP biosynthetic process
GO:0006184	GTP catabolic process
GO:0006531	aspartate metabolic process
GO:0014074	response to purine-containing compound
GO:0044208	'de novo' AMP biosynthetic process
GO:0046040	IMP metabolic process
GO:0060359	response to ammonium ion
GO:0071257	cellular response to electrical stimulus