InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nudt1

Summary

InnateDB Protein

IDBP-206858.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nudt1

Protein Name

nudix (nucleoside diphosphate linked moiety X)-type motif 1

Synonyms

Mth1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000071778

InnateDB Gene

IDBG-206856 (Nudt1)

Protein Structure

UniProt Annotation

Function

Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. {ECO:0000269PubMed:7592783}.

Subcellular Localization

Cytoplasm. Nucleus. Nucleus membrane. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}.

Disease Associations

Tissue Specificity

High expression levels detected in thymus, liver, spleen, kidney, testis and large intestine, with lower levels detected in brain, heart, lung and stomach (at protein level). Expressed in kidney, liver and small intestine. {ECO:0000269PubMed:7592783}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
GO:0016787	hydrolase activity
GO:0030515	snoRNA binding
GO:0035539	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
GO:0046872	metal ion binding
GO:0047693	ATP diphosphatase activity

Biological Process

GO:0006184	GTP catabolic process
GO:0006200	ATP catabolic process
GO:0006203	dGTP catabolic process
GO:0006281	DNA repair
GO:0042262	DNA protection
GO:0046061	dATP catabolic process