Version 5.4
| Mus musculus Protein: Smox | |||||||||||||
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| Summary | |||||||||||||
| InnateDB Protein | IDBP-207114.6 | ||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
| Gene Symbol | Smox | ||||||||||||
| Protein Name | spermine oxidase | ||||||||||||
| Synonyms | |||||||||||||
| Species | Mus musculus | ||||||||||||
| Ensembl Protein | ENSMUSP00000028806 | ||||||||||||
| InnateDB Gene | IDBG-207112 (Smox) | ||||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||||
| Function | Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal. | ||||||||||||
| Subcellular Localization | Cytoplasm {ECO:0000269PubMed:14764092}.Isoform 2: Cytoplasm. Nucleus. | ||||||||||||
| Disease Associations | |||||||||||||
| Tissue Specificity | Widely expressed. Isoform 1 and isoform 2 are expressed at higher level in brain and skeletal muscle. Isoform 7 is found in brain and spleen, isoform 10 is widely expressed but found at lower level in heart, kidney, liver and lung. {ECO:0000269PubMed:14764092}. | ||||||||||||
| Comments | |||||||||||||
| Interactions | |||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||||
| PDB ID | MGI:2445356 | ||||||||||||
| InterPro |
IPR002937
Amine oxidase IPR003953 FAD binding domain IPR006076 FAD dependent oxidoreductase |
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| PFAM |
PF01593
PF00890 PF01266 |
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| PRINTS | |||||||||||||
| PIRSF | |||||||||||||
| SMART | |||||||||||||
| TIGRFAMs | |||||||||||||
| Post-translational Modifications | |||||||||||||
| Modification | |||||||||||||
| Cross-References | |||||||||||||
| SwissProt | Q99K82 | ||||||||||||
| PhosphoSite | PhosphoSite-Q99K82 | ||||||||||||
| TrEMBL | Q3UPW5 | ||||||||||||
| UniProt Splice Variant | |||||||||||||
| Entrez Gene | 228608 | ||||||||||||
| UniGene | Mm.136586 | ||||||||||||
| RefSeq | NP_663508 | ||||||||||||
| MGI ID | |||||||||||||
| MGI Symbol | Smox | ||||||||||||
| OMIM | |||||||||||||
| CCDS | CCDS16763 | ||||||||||||
| HPRD | |||||||||||||
| IMGT | |||||||||||||
| EMBL | AF495851 AF495852 AF495853 AF498364 AJ567473 AJ567474 AJ567475 AJ567476 AJ567477 AJ567478 AJ567479 AJ567480 AK143129 AL831731 AL831781 BC004831 CH466519 | ||||||||||||
| GenPept | AAH04831 AAN32908 AAN32909 AAN32910 AAN32915 BAE25279 CAD98866 CAD98867 CAD98868 CAD98869 CAD98870 CAD98871 CAD98872 CAD98873 CAM20374 CAM20375 CAM20376 CAM20378 CAM20379 CAM24528 CAM24529 CAM24530 CAM24531 CAM24532 EDL28321 | ||||||||||||