InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prnp

Summary

InnateDB Protein

IDBP-207184.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prnp

Protein Name

prion protein

Synonyms

AA960666; AI325101; CD230; Prn-i; Prn-p; PrP; PrP; prP27-30; prP33-35C; PrPC; PrPSc; Sinc;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000088833

InnateDB Gene

IDBG-260830 (Prnp)

Protein Structure

UniProt Annotation

Function

May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains. {ECO:0000250, ECO:0000269PubMed:12732622, ECO:0000269PubMed:16492732, ECO:0000269PubMed:19242475, ECO:0000269PubMed:19568430}.

Subcellular Localization

Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of CU(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis. {ECO:0000269PubMed:11571277, ECO:0000269PubMed:12732622, ECO:0000269PubMed:16923158, ECO:0000269PubMed:9837873}.

Disease Associations

Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.

Tissue Specificity

Highly expressed in the brain, lung, kidney and heart. Expressed at low levels in the liver and spleen. {ECO:0000269PubMed:16492732, ECO:0000269PubMed:19568430}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 59 interaction(s) predicted by orthology.

Experimentally validated
Total	55 [view]
Protein-Protein	55 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	59 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0015631	tubulin binding
GO:0042802	identical protein binding
GO:0043008	ATP-dependent protein binding
GO:0051087	chaperone binding

Biological Process

GO:0001933	negative regulation of protein phosphorylation
GO:0006139	nucleobase-containing compound metabolic process
GO:0006878	cellular copper ion homeostasis
GO:0006979	response to oxidative stress
GO:0007611	learning or memory
GO:0032689	negative regulation of interferon-gamma production
GO:0032700	negative regulation of interleukin-17 production
GO:0032703	negative regulation of interleukin-2 production
GO:0032880	regulation of protein localization
GO:0043066	negative regulation of apoptotic process
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0046007	negative regulation of activated T cell proliferation
GO:0046686	response to cadmium ion
GO:0046688	response to copper ion
GO:0050860	negative regulation of T cell receptor signaling pathway
GO:0051260	protein homooligomerization
GO:0070885	negative regulation of calcineurin-NFAT signaling cascade
GO:1901379	regulation of potassium ion transmembrane transport

Cellular Component

GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0031225	anchored component of membrane
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome