Mus musculus Gene: Prnp
Summary
InnateDB Gene IDBG-260830.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prnp
Gene Name prion protein
Synonyms AA960666; AI325101; CD230; Prn-i; Prn-p; PrP; PrP; prP27-30; prP33-35C; PrPC; PrPSc; Sinc;
Species Mus musculus
Ensembl Gene ENSMUSG00000079037
Encoded Proteins
prion protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171867:
The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:131909928-131938429
Strand Forward strand
Band F2
Transcripts
ENSMUST00000091288 ENSMUSP00000088833
ENSMUST00000142070
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 59 interaction(s) predicted by orthology.
Experimentally validated
Total 55 [view]
Protein-Protein 55 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 59 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0015631 tubulin binding
GO:0042802 identical protein binding
GO:0043008 ATP-dependent protein binding
GO:0051087 chaperone binding
Biological Process
GO:0001933 negative regulation of protein phosphorylation
GO:0006139 nucleobase-containing compound metabolic process
GO:0006878 cellular copper ion homeostasis
GO:0006979 response to oxidative stress
GO:0007611 learning or memory
GO:0032689 negative regulation of interferon-gamma production
GO:0032700 negative regulation of interleukin-17 production
GO:0032703 negative regulation of interleukin-2 production
GO:0032880 regulation of protein localization
GO:0043066 negative regulation of apoptotic process
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0046007 negative regulation of activated T cell proliferation
GO:0046686 response to cadmium ion
GO:0046688 response to copper ion
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0051260 protein homooligomerization
GO:0070885 negative regulation of calcineurin-NFAT signaling cascade
GO:1901379 regulation of potassium ion transmembrane transport
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031225 anchored component of membrane
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
NCAM1 interactions pathway
Axon guidance pathway
Developmental Biology pathway
NCAM signaling for neurite out-growth pathway
KEGG
Prion diseases pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Developmental Biology pathway
NCAM signaling for neurite out-growth pathway
NCAM1 interactions pathway
Axon guidance pathway
NCAM signaling for neurite out-growth pathway
NCAM1 interactions pathway
Axon guidance pathway
Developmental Biology pathway
KEGG
Prion diseases pathway
INOH
PID BIOCARTA
PID NCI
Glypican 1 network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.648
RefSeq NM_001278256 NM_011170
OMIM
CCDS CCDS16766
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas