InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Prnp

Summary

InnateDB Gene

IDBG-260830.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prnp

Gene Name

prion protein

Synonyms

AA960666; AI325101; CD230; Prn-i; Prn-p; PrP; PrP; prP27-30; prP33-35C; PrPC; PrPSc; Sinc

Species

Mus musculus

Ensembl Gene

ENSMUSG00000079037

Encoded Proteins

IDBP-207184

prion protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171867:
The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:131909928-131938429

Strand

Forward strand

Band

Transcripts

ENSMUST00000091288	ENSMUSP00000088833
ENSMUST00000142070

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 59 interaction(s) predicted by orthology.

Experimentally validated
Total	55 [view]
Protein-Protein	55 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	59 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0015631	tubulin binding
GO:0042802	identical protein binding
GO:0043008	ATP-dependent protein binding
GO:0051087	chaperone binding

Biological Process

GO:0001933	negative regulation of protein phosphorylation
GO:0006139	nucleobase-containing compound metabolic process
GO:0006878	cellular copper ion homeostasis
GO:0006979	response to oxidative stress
GO:0007611	learning or memory
GO:0032689	negative regulation of interferon-gamma production
GO:0032700	negative regulation of interleukin-17 production
GO:0032703	negative regulation of interleukin-2 production
GO:0032880	regulation of protein localization
GO:0043066	negative regulation of apoptotic process
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0046007	negative regulation of activated T cell proliferation
GO:0046686	response to cadmium ion
GO:0046688	response to copper ion
GO:0050860	negative regulation of T cell receptor signaling pathway
GO:0051260	protein homooligomerization
GO:0070885	negative regulation of calcineurin-NFAT signaling cascade
GO:1901379	regulation of potassium ion transmembrane transport

Cellular Component

GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0031225	anchored component of membrane
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome