InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pycr2

Summary

InnateDB Protein

IDBP-207359.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pycr2

Protein Name

pyrroline-5-carboxylate reductase family, member 2

Synonyms

1810018M05Rik; P5cr2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027802

InnateDB Gene

IDBG-207357 (Pycr2)

Protein Structure

UniProt Annotation

Function

Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004735	pyrroline-5-carboxylate reductase activity

Biological Process

GO:0006561	proline biosynthetic process
GO:0055114	oxidation-reduction process
GO:0055129	L-proline biosynthetic process

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:1277956

InterPro

IPR000304 Pyrroline-5-carboxylate reductase
IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like
IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal

PFAM

PF03807

PRINTS

PIRSF

PIRSF000193

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q922Q4