InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ephx1

Summary

InnateDB Protein

IDBP-207432.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ephx1

Protein Name

epoxide hydrolase 1, microsomal

Synonyms

AI195553; Eph-1; Eph1; mEH;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000047551

InnateDB Gene

IDBG-207430 (Ephx1)

Protein Structure

UniProt Annotation

Function

Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.

Subcellular Localization

Microsome membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0033961	cis-stilbene-oxide hydrolase activity

Biological Process

GO:0006725	cellular aromatic compound metabolic process
GO:0009636	response to toxic substance
GO:0014070	response to organic cyclic compound
GO:0019439	aromatic compound catabolic process

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:95405

InterPro

IPR000073 Alpha/beta hydrolase fold-1
IPR000639 Epoxide hydrolase-like
IPR010497 Epoxide hydrolase, N-terminal
IPR016292 Epoxide hydrolase
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF00561
PF06441

PRINTS

PR00111
PR00412

PIRSF

PIRSF001112

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt